SHAKE BOTTLE WELL BEFORE USE. FOR ADDED EASE, POUR DROPS ONTO A SPOON AND GIVE ORALLY. Product does not require refrigerated shipping; refrigeration only required AFTER opening. Compare our price to other brands, that sell their patented strains of Lactobacillus Reuteri intended for use with Colic, which deliver half the amount of L. Reuteri per dose while giving you half the volume. BioAmicus Reuteri provides you more probiotic per dollar compared to other producers of Lactobacillus Reuteri.